Genetic background determines response to hemostasis and thrombosis

Genetic background determines response to hemostasis and thrombosis

BACKGROUND Thrombosis is the fatal and disabling consequence of cardiovascular diseases, the leading cause of mortality and morbidity in Western countries. Two inbred mouse strains, C57BL/6J and A/J, have marked differences in susceptibility to obesity, atherosclerosis, and vessel remodeling. However, it is unclear how these diverse genetic backgrounds influence pathways known to regulate throm...

Thrombosis and Hemostasis

We recently demonstrated that blockade of the platelet adhesion receptor glycoprotein (GP) Ib protects mice from ischemic stroke. Although von Willebrand factor (VWF) is the major ligand for GPIb , GPIb can engage other counterreceptors on endothelial cells, platelets, and leukocytes (eg, Mac-1 or P-selectin) potentially involved in stroke outcome. To further analyze whether VWF is of particula...

Thrombosis and Hemostasis

1Inserm, Unite 872, Centre de recherche des Cordeliers, Paris, France; 2Université Pierre et Marie Curie-Paris 6, Unite Mixte de Recherche S 872, Centre de recherche des Cordeliers, Paris, France; 3Université Paris Descartes, Unite Mixte de Recherche S 872, Centre de recherche des Cordeliers, Paris, France; and 4Department of Drug Discovery and Development, Italian Institute of Technology, Geno...

[Hemostasis and thrombosis].

Thrombosis and Hemostasis

Our previous studies with genomic minigenes have demonstrated that an engineered small nuclear RNA-U1 (U1 5a) partially rescued coagulation factor VII (FVII) mRNA processing impaired by the 9726 5G>A mutation. Here, to evaluate the U1 5a effects on FVII function, we devised a full-length FVII splicingcompetent construct (pSCFVII-wt). This construct drove in COS-1 cells the synthesis of properly...